If you use Zetia and warfarin together, your doctor may want to monitor you more closely during your treatment. Lipitor is available in a generic form called atorvastatin. This includes grapefruit and grapefruit juice. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). However, its important that you dont stop taking Zetia without first talking with your doctor. Get answers to some frequently asked questions about Zetias side effects. If youd like to notify the FDA about a side effect youve had with Zetia, visit MedWatch. You can take Zetia at any time during the day, but try to take your dose around the same time each day. Over time, plant sterols can build up in your blood vessels and raise your risk of heart disease. And talk with your doctor if you have any questions about eating certain foods with Zetia. Zetia is sometimes used with medications in the statin drug class. Zetia can also be used with statin drugs in adults. Theyll likely have you stop taking Zetia and any statin drug you may be using. Zetia is a brand-name drug that contains the active drug ezetimibe. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . The generic is considered to be as safe and effective as the original drug. The following information describes dosages that are commonly used or recommended. If your doctor confirms you had a serious allergic reaction to Zetia, they may have you switch to a different treatment. * For more information about this side effect, see " Zetia: Side effects explained " below. They often originate at the base of the skull and spreading on the back of the head and neck. In the video she posted on Thursday, the "Real Housewives of New York City" alum detailed her suffering from a severe dehydration issue and shared that her doctor . Zetia shouldnt cause weight gain or weight loss. Allergic reaction. It also isnt known how many adults and children experienced joint pain in clinical studies of Zetia used to treat other conditions. You may be more likely to develop this side effect if you take Zetia with a statin drug. * Sex and gender exist on spectrums. Theyll guide you with suggestions they may have to relieve these side effects. Using Zetia with medications in the fibrate drug class raises your risk of gallstones even more. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. These problems can include muscle pain and muscle weakness, and rarely, muscle breakdown. MS: Can the Mediterranean diet help preserve cognitive health? Fenofibrate is a drug used to lower your triglyceride levels. Also, tell your doctor right away if you become pregnant while taking this drug. However, it isnt known how Zetia may affect these risks. However, you may need to avoid grapefruit if you take Zetia with a statin, another type of cholesterol medication. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. (A class of drugs is a group of medications that work in a similar way.) No, stopping Zetia shouldnt cause any side effects. Zetia can interact with several other medications. Drugs in this class prevent your small intestine from absorbing cholesterol. Tell your doctor if youre experiencing bothersome side effects from Zetia. To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine). For information on the effectiveness of Zetia, see the Zetia uses section below. If you have questions about using Zetia and cholestyramine together, talk with your doctor. Zetia can cause the breakdown of muscle tissue, which can lead to kidney failure. Its intestinal molecular target is the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter. For more information, see the How Zetia works section below. Dont take an extra dose to make up for your missed dose. If you develop increased liver enzyme levels, your doctor may make changes to your treatment plan. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Some people experience mild side effects with Zetia. For example, in studies, some people had to stop taking the drug because their liver enzyme levels increased. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about . Zetia has been found in breast milk during animal studies. An allergic reaction is possible after using Zetia. Talk with your doctor right away if you have fever or chills with your joint pain. muscle pain while taking ezetimibe with a statin. The primary symptom of OI is lightheadedness or fainting. However, studies have found both Zetia and Lipitor to be effective for lowering cholesterol. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. Zetia belongs to a class of drugs called cholesterol absorption inhibitors. If you have joint pain while taking Zetia, you may also experience swelling, redness, or weakness in your joints. Zetia side effects. Symptoms of atherosclerosis may include confusion, fatigue (lack of energy), trouble breathing, or pain in your chest, arms, or legs. These symptoms could be life threatening and require immediate medical care. But some people have reported memory loss, confusion, and forgetfulness while taking a statin drug. Medications in the fibrate drug class may increase the amount of cholesterol thats stored in your gallbladder. Or they may recommend that you stop taking the medication. This can cause Zetia to be less effective. The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. I am a stay at home mama to a sweet baby girl, and wife to an amazing h. While taking Zetia, tell your doctor right away if you experience extreme muscle pain, muscle tenderness, or dark-colored urine. Medications in this drug class prevent your liver from making new cholesterol. If youre pregnant or breastfeeding, or if youre planning to become pregnant or breastfeed, tell your doctor. But it may be a sign that your liver isnt working as well as it should. The following lists contain some of the key side effects that may occur while taking Zetia. Brand-name medications usually cost more than generics. So if youre taking Zetia with a statin drug, you may need to avoid eating grapefruit or drinking grapefruit juice during your treatment. It only comes in a strength of 10 milligrams (mg). Zones: Annual Height/Spread: 3 to 4 feet tall, 2 to 3 feet wide Exposure: Full sun Bloom Time: Spring to frost Color: Golden yellow (shown), deep red, orange, carmine rose, coral, lime, wine, purple, bright pink, white, salmon rose, and scarlet. After stopping Zetia treatment, their liver enzymes levels went back down. Examples of other drugs that may be used to treat primary high cholesterol include: Examples of other drugs that may be used to treat mixed high cholesterol include: Examples of other drugs that may be used to treat homozygous familial hypercholesterolemia include: Examples of other drugs that may be used to treat homozygous sitosterolemia include: You may wonder how Zetia compares with other medications that are prescribed for similar uses. As with all medications, the cost of Zetia can vary. This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. Zetia is meant to be used as a long-term treatment. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. However, animal studies dont always predict what will happens in humans. Statins, another medication for high cholesterol, are known to cause muscle-related side effects. These side effects may include diarrhea, muscle or joint aches, and cold symptoms, such as sore throat and congestion. You can learn more about how we ensure our content is accurate and current by reading our. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. New evidence shows that the drug makers Merck and Schering-Plough have conducted several studies of their popular cholesterol medicine Zetia that raise questions about its risks to the liver, but . Energy Drinks, such as Red Bull, should be avoided in those with POTS. So stopping Zetia may lead to an increase in your cholesterol levels. Zetia and Crestor are both brand-name drugs. They may have a preference for one version or the other. In clinical studies, Zetia has been found to be effective for treating mixed high cholesterol when used with fenofibrate. If left untreated, it can cause your kidneys to stop working properly. Some people have mild symptoms, while for others it can have a big impact on their everyday lives. Mild side effects of Zetia when taken with a statin (another kind of cholesterol -lowering drug) may include: infection, such as a respiratory . Other interactions can increase side effects or make them more severe. Zetia is also available in a generic form called ezetimibe. This can increase your risk of side effects from either medication. During your Zetia treatment, consider keeping notes on any side effects youre having. Postural orthostatic tachycardia syndrome (POTS) is a condition characterized by lightheadedness or dizziness when standing and a racing heart. Zetia is sometimes used with medications in the statin drug class. Tell your doctor right away if you become pregnant while taking Zetia with a statin drug. However, you shouldnt stop taking Zetia without first talking with your doctor. Postural Orthostatic Tachycardia Syndrome (POTS) is a blood flow disorder that causes a sudden spike in heartbeat with no change in blood pressure when going from a horizontal or seated to a standing position. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). Zetia can cause mild or serious side effects. In addition, Zetia may be used with fenofibrate to treat mixed hyperlipidemia. When taken together, it should be administered at least 2 hours before or 4 hours after a bile acid sequestrant. Below are medications that can interact with Zetia. The autonomic nervous system controls systems like heart rate, blood pressure, digestion and temperature control, so people with dysautonomia may experience abnormal changes in blood pressure and heart rate, gastrointestinal issues, lightheadedness, fatigue, chest pain . This lack of blood to the brain and other organs can cause a variety of symptoms, including: Fainting. Depending on your age or other medical conditions you may have, you may be at higher risk of developing rhabdomyolysis while taking Zetia. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. They may have suggestions depending on your weight and health goals. (Mixed hyperlipidemia is also known as mixed high cholesterol.). Zetia is also available in a generic form called ezetimibe. Before taking Zetia, talk with your doctor about your health history. Some people may develop mild or serious side effects during Zetia treatment. Zetia is FDA-approved to lower your total cholesterol level, and triglycerides are one part of your total cholesterol level. The autonomic nervous system is in charge of all bodily functions that we don't have to think about, such as: The sympathetic nervous system is part of the autonomic nervous system. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. This may increase your risk of side effects. For treatment of mixed hyperlipidemia, Zetia is indicated to reduce total cholesterol, LDL cholesterol, non-HDL cholesterol, and ApoB. For mixed high cholesterol, Zetia is FDA-approved to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet and is taken with other drugs. Recently, POTS has been diagnosed in some people who have had COVID-19. If your doctor has prescribed Zetia and youre interested in using ezetimibe instead, talk with your doctor. Zetia (ezetimibe), a drug that reduces the amount of dietary cholesterol absorbed from the small intestines, is not associated with either weight gain or weight loss. You may find your symptoms are worse in the morning, and they may change from day to day. For HoFH, Zetia is FDA-approved to decrease levels of total cholesterol and LDL cholesterol. diarrhea*. POTS is a kind of dysautonomia or autonomic nervous disorder. Learn about the side effects it can cause and how to manage them. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. Statins shouldnt be used during pregnancy. However, some people have reported experiencing memory loss when taking statin drugs. Each type is described below in more detail. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you think youve taken too much of this drug, call your doctor. The cause of the disorder is unknown. Zetia can cause certain side effects, some of which are more common than others. Statin drugs may pass into breast milk. But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. For more information on these side effects, see Side effect details below. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. Zetias mechanism of action is considered complementary to that of statins and fenofibrate. See the Zetia prescribing information for details. Talk with your doctor about birth control options that may be best for you. Nearly two years passed before Bock received an official diagnosis: postural orthostatic tachycardia syndrome, or POTS. Learn more about how grapefruit may interact with medications. Physicians who treat dysautonomia can be located on our Physician List. Postural orthostatic tachycardia syndrome (POTS) is a condition that causes a number of symptoms when you transition from lying down to standing up, such as a fast heart rate, dizziness and fatigue. Females who could become pregnant should use birth control while taking Zetia with a statin drug. Then theyll monitor whether the drug is working for you and whether you experience any side effects. Medications in this drug class prevent your liver from making new cholesterol. See the Mild side effects and Serious side effects sections above for more information. Both Zetia and Lipitor come as tablets that are swallowed. Here we look at how Zetia and Crestor are alike and different. Some people witness mild symptoms, some have a big impact on their lives due . Youll likely take Zetia once a day. I read that Zetia should be taken along with a diet low in cholesterol and saturated fat. * Zetia is also approved to treat these conditions in children ages 10 years and older. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. Also, if you have a history of heavy drinking or liver damage, be sure to tell your doctor before you begin taking Zetia. For this purpose, Zetia may be used alone or with fenofibrate. Cholesterol absorption inhibitors prevent your small intestine from absorbing cholesterol. Zetia generally costs less than Lipitor. 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